girk|Emerging roles for G protein,mom son swap

G Protein-Coupled Inwardly-Rectifying Potassium Channels (GIRK channels) are channels found in the brain that play a crucial role in the inhibitory effects of neurotransmitters.

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come toggirkether to form GIRK ion channels.

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons girkthrough GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission.

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